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To put it shortly, long-term therapy with semaglutide extended patients lives and lowered their risk of ending up in a hospital for cardiovascular reasons

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Food and Drug Administration GDPR: General Data Protection Regulation GLP-1 RA: Glucagon-like peptide-1 receptor agonist HCO: Healthcare Organization HIPAA: Health Insurance Portability and Accountability Act HR: Hazard ratio ICD-10-CM: International Classification of Diseases, Tenth Revision, Clinical Modification MAKE: Major adverse kidney events MALO: Major adverse liver outcomes MASH: Metabolic dysfunction-associated steatohepatitis MASLD: Metabolic dysfunction-associated steatotic liver disease MACE: Major adverse cardiovascular events MD: Mean difference NAFLD: Non-alcoholic fatty liver disease (historical term) NNT: Number needed to treat PSM: Propensity Score Matching RCT: Randomized controlled trial SGLT2i: Sodium-glucose cotransporter-2 inhibitor SMD: Standardized mean difference STROBE: Strengthening the Reporting of Observational Studies in Epidemiology SUCRA: Surface under the cumulative ranking curve T2DM: Type 2 diabetes mellitus References Rinella ME, Lazarus JV, Ratziu V, Francque SM, Sanyal AJ, Kanwal F, et al

Because of its high incidence, mortality, disability rate, recurrence and medical costs, stroke has emerged as a serious health problem of general concern

Together these give it a much longer half-life (~2030 hours vs