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Identifying strategies to target the metabolic flexibility of tumours

Patients with progressive kidney failure and usually with less than 10 to 15 percent function usually need dialysis to clear toxins from the body

First, this analysis was based on aggregated arm-level data rather than individual participant data, which limited the ability to adjust for patient-level heterogeneity, including comorbidities and concomitant therapies

The honest answer is that no clinically validated human dosing protocol exists

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Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction