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Finally, to expand on the opportunity for NMDA receptor antagonism as a complementary pharmacological partner to GLP-1 receptor agonism, we pretreated DIO mice with semaglutide for 14 days and subsequently randomized the mice to stay on semaglutide in combination with either GLP-1MK-801 or the GLP-1 monotherapy (Fig

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The results revealed that 12-week treatment with liraglutide led to significant improvements in intrinsic connectivity within the default mode network, as assessed by resting-state fMRI