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Starting with the question of whether semaglutide has the potential to enhance sport performance, as of early 2026, theres no published, peer-reviewed clinical trials directly measuring whether GLP-1 agonists improve athletic performance in trained, healthy athletes

doi: 10.3389/fimmu.2021.670338 89 KhmaladzeISaxenaANandakumarKSHolmdahlR

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1 For example, liraglutide treatment led to substantial PASI score reduction alongside improvements in both body mass index (BMI) and hemoglobin A1C (HbA1c)

If the symptoms are caused by a "detox" response, they may persist for a few days

As we move forward, it is imperative that patients and healthcare providers work together to navigate this complex landscape, leveraging the latest research and clinical insights to make informed decisions that best support individual health goals