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In such cases, the treatment strategies are likely to target systemic metastases, while the removal of metastatic LNs and targeting of non-metastatic draining LNs may potentially augment the effectiveness of immune checkpoint blockade (ICB) treatment (52, 63)

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This range was used as it allowed us to see the effects of treating cells with more EVs than would be present in a natural infection, EV levels present during a natural infection (1 10 6 to 1 10 5 ) and the effects of having fewer EVs than would occur in a natural infection

As shown in Figure 2 , BCAA metabolites possess diverse biological functions under both physiological and pathological conditions

Kindt MV, Heikkila RE, Nicklas WJ

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