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2.2 Mechanism of ferroptosis occurrence 2.2.1 Core regulatory pathways 2.2.1.1 System xc /GSH/GPX4 signaling as primary regulatory hub Ferroptosis regulation is widely recognized as primarily involving the constitutive inhibition of system Xc , which triggers a cascade leading to glutathione (GSH) exhaustion and GPX4 functional impairment

The fact that AOD-9604 showed zero effect on this marker confirms its selectivity at the molecular level and demonstrates that fat metabolism effects occur through an entirely different mechanism than growth hormones systemic actions