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4 What to know about orforglipron: An investigational oral GLP-1

a compensatory increase in orexigenic neuropeptide tone

Dispose of the pen correctly: After use, discard the pen in a sharps disposal container as instructed

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Sleep-inducing factor: a neuropeptide

The signaling through GLP-1R leads to improved glycemic control and weight management, ultimately resulting in approval of GLP-1 receptor agonist medications for the treatment of T2DM and obesity [1]