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Glucose-6-phosphate dehydrogenase and NADPH redox regulates cardiac myocyte L-type calcium channel activity and myocardial contractile function

Weight loss ranged from 12 to 25 pounds

This balance is crucial for protecting cells against oxidative damage

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Such alterations have been noted in individuals with type 2 diabetes, obesity, and metabolic syndrome, though the precise mechanisms remain an active area of research

N Engl J Med 375:311322 Rizvi AA, Patti AM, Giglio RV et al (2015) Liraglutide improves carotid intima-media thickness in patients with type 2 diabetes and non-alcoholic fatty liver disease: an 8-month prospective pilot study