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The principle of using the minimum effective intervention applies, particularly given the lack of clinical trial data supporting combination therapy and SmPC cautions against coadministration with other weight-loss medicines

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Interestingly, studies showed that vitamin D supplementation improved behavioral symptoms in ASD children, including stereotypy, irritability, and eye contact, as evaluated by the Autism Behavior Checklist and/or the Childhood Autism Rating Scale 39,40,41

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In the OASIS-4 trial, the once-daily 25 mg tablet produced an average weight loss of 13.6% over 64 weeks among all participants who started the trial