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The American Journal of Medicine , 133 , 901907

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Separate PCA in patient and control groups identified three similar components with the same metabolite loadings exceeding 0.5 on corresponding components in each group

The consumption of free l-carnitine and free CoA due to the accumulation of long chain acyl groups can limit acetyl-l-carnitine synthesis, since free l-carnitine levels are critical for maintaining the buffering capacity of CPTs

Future therapeutic directions should focus on developing more targeted Lipid ROS inhibitors and utilizing advanced imaging techniques to monitor real-time dynamic changes in Lipid ROS levels