Its crucial for researchers to differentiate this temporary, regenerative response from a true adverse reaction or comedogenic effect
GSH deficiency as evidenced by a decrease in the GSH/GSSG ratio manifests itself largely through an increased susceptibility to oxidative stress, and the resulting damage is thought to be involved in SARS-CoV-2 infection leading to COVID-19 disease (6, 7, 39, 4353)
That said, for some people it simply comes down to their skin not responding well to certain ingredients, which may result in an unwanted reaction to skincare products (known as irritant contact dermatitis)
doi:10.1016/0008-8749(90)90184-s 28
5A-1MQ-treated mice switched from WD to LD (WD/LD-T) showed a rather reduced relative abundance of Akkermansia compared to vehicle-treated DIO animals switched from WD to LD (WD/LD-V), suggesting a unique microbiome mechanism associated with weight loss in the vehicle-treated group switched from WD to LD compared to the 5A-1MQ-treated group that underwent the same diet switch
doi: 10.1016/J.RADMP.2020.10.001 205 VicidominiCPalumboRMocciaMRovielloGN