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Although earlier studies reported an incidence of 0.30.7%, recent publications have shown an overall incidence of 3.28.9%, with more than 75% of cases occurring in men between 45 and 65 years of age (1,2)

Unfortunately, the poor blood flow devoid of adequate oxygen remains uncorrected and the underlying disease may evolve into more serious problems such as blood clots, bleeding, infection of the skin in legs, and sores that are slow to heal

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Concomitantly, we measured increased pyruvate levels in mutant compared to control cells (Supplementary Fig

DOI: 10.3892/br.2017.885

Eligibility Check : Verify compliance with criteria, such as a BMI of 30 or higher