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463,464 It reduces inflammation and improves symptoms primarily by suppressing the effects of TNF- and is typically used in patients who do not respond to or are intolerant to conventional treatments such as 5-aminosalicylic acid

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With regards to codes with older time values, we agree that it is important to use the most recent data available regarding time, and we note that when many years have passed between time is measured, significant discrepancies can occur