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Adverse Reactions: The most common adverse reactions, reported in 5% are nausea, diarrhea, constipation, vomiting, injection site reactions, headache, hypoglycemia, dyspepsia, fatigue, dizziness, abdominal pain, increased lipase, upper abdominal pain, pyrexia, and gastroenteritis
Other important safety considerations include risk of hypoglycaemia when combined with insulin or sulfonylureas, potential gallbladder disease, and the need for monitoring in patients with pre-existing diabetic retinopathy
Here are some practical approaches: Gradual Dose Escalation: Starting with a lower dose and gradually increasing can help mitigate side effects
3 Conversely, the incidence of thyroid disorder was associated more with the PD-1/PD-L1 inhibitors than with CTLA-4 inhibitors, which is consistent with data presented in a systematic review of the literature
Supplementing carnitine with omega-3 fatty acids, choline, alpha lipoic acid, Vitamin C and B vitamins may be helpful