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They did however comment in their New England Journal of Medicine article that the affinity of lixisenatide for the GLP-1 receptor was up to four times greater than that of human GLP-1and there have been neuroprotective actions shown in animal models of Alzheimers disease. Together, I suspect these were likely strong rationales driving their choice of the use of Lixisenatide

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Effect of glucagon-like peptide-1 receptor agonists on lipid profiles among type 2 diabetes: a systematic review and network meta-analysis

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Nov 2022;43(4):324-338