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This highlights the necessity for future vitamin D research to leverage larger sample sizes and datasets with more comprehensive information to enhance the robustness of investigations in this domain

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Meta-regression analyses for homocysteine, cysteine, and vitamin B12 only showed that publication year was significantly associated with ES, as shown in eFig

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2017 Jul;55(6):569-572

miR-145 was also shown to modulate IGF-1 signaling pathway by directly targeting IGF-1R in HCC (Su et al., 2009), but its role other cancer remained unknown ( Amplified IGF-1/IGF-1R signaling has been associated with increased relative risk for development of colorectal cancer (CRC) as well as CRC metastasis, and resistance to chemotherapeutic drugs (Weber et al., 2002