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a meaningful result, but one that will require replication in larger, longer trials before combination therapy of this kind becomes a standard clinical option

The onset and recurrence of depression have been linked to diverse metabolic factors, including hyperglycemia, dyslipidemia, and insulin resistance

Its main mechanism is directly tied to chromodulin, a chromium-dependent protein that augments the signaling of insulin receptors

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Data availability Data is available from the corresponding author on request

However, significant weight loss from Wegovy may eventually require adjustments to your thyroid medication, as thyroid hormone doses are typically based on your weight