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3.5 Meta-analysis The included studies showed substantial heterogeneity (I 2 = 99.6%, p 0.05), supporting the conclusion of comparable efficacy and the lack of a clear doseresponse relationship

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This is particularly relevant in complex tissue injuries where multiple repair processes need coordination

Treatments (Clinical) Clinical management of Crohns disease follows a treat-to-target strategy as outlined in the ACG Clinical Guidelines for Crohns Disease (2018, updated guidance 2024) with the goal of achieving and maintaining deep remission (clinical, endoscopic, and histologic remission)

Many patients report feeling increased alertness and reduced fatigue within hours of injection

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