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ClinicalTrials.gov (2024)
The increase in eumelanin provides enhanced photoprotection against ultraviolet (UV) radiation
While beneficial for normal growth, it poses a theoretical risk of accelerating the growth of existing or dormant cancers (for example, prostate, breast, colon) by inhibiting apoptosis (programmed cell death) and driving cell replication
Major clinical trials enrolled thousands of participants without identifying depression as a primary safety signal
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