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Careful and targeted patient selection are required, alongside robust education and novel technologies to monitor glucose and ketone levels to mitigate the risks and enhance the beneficial effects of SGLT2i and GLP-1 RA therapy

TRT Nations approach to treatment incorporates this understanding, recognizing that sustainable weight loss requires addressing hormonal imbalances, metabolic dysfunction, and insulin resistance alongside the weight-reduction effects of tirzepatide

"If this finding continues to gain evidence, GLP-1s might be a better option for low T than testosterone replacement therapy (TRT) in obese men as GLP-1 medications preserve fertility, whereas TRT tends to be harmful to male reproductive/sperm function," he added.

Glucagon-like receptor agonists and next-generation incretin-based medications: metabolic, cardiovascular, and renal benefits

These findings emphasize the need for a personalized approach in clinical decision-making, balancing efficacy goals with tolerability to optimize adherence and long-term outcomes

McKay NJ et al