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(2013) conducted a formal pharmacokinetic study in nine healthy male volunteers, establishing a biphasic profile: a rapid distribution phase of approximately 7.6 minutes followed by an elimination phase of approximately 2.5 hours

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Analysis of the male partners semen revealed abnormalities, particularly in sperm morphology, with a notable predominance of elongated spermatozoa

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Surgical Margins: Complete resection with negative margins (R0) is the strongest predictor of long-term survival

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