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As the dominant G-actin sequestering protein in mammalian cells, TB-500 binds globular actin with high affinity (Kd ~0.5 M) through a sophisticated triple-contact mechanism involving Lys-3, Lys-18, and Lys-38 residues, preventing spontaneous actin polymerization while maintaining a readily mobilizable reservoir for rapid cytoskeletal reorganization

In this study, APP-treated serum exhibited superior ROS scavenging capacity to untreated serum, underscoring a substantial enhancement of antioxidative potential induced by plasma treatment

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doi: 10.2147/DMSO.S220180 17 MonamiMCremascoFLamannaCMarchionniNMannucciE