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The glycosaminoglycan (GAG, a proteoglycan side chain) content decreases and catabolic matrix metalloproteinase (MMP) activity and denatured collagen content increases - the latter creating a more rigid IVD matrix reviewed in [2, 5, 6]

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Some studies suggest that a dosage of 2-3 grams per day can enhance physical performance, while others recommend a lower dosage of around 500 mg per day

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