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The N-terminal glycine amino group donates one nitrogen ligand to the copper, the imidazole nitrogen of the histidine side chain donates a second nitrogen ligand, and the deprotonated amide nitrogen of the Gly-His peptide bond donates a third nitrogen ligand

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Epigenetically, phytochemicals, notably polyphenols and terpenoids, can alter histone acetylation and DNA methylation, as well as modulate miRNA expression, restoring silenced tumor suppressor genes and reducing oncogene expression, yielding antiproliferative, pro-apoptotic, and resensitizing effects (Roy and Datta, 2019)

During puberty, melatonin secretion levels decrease, which slowly decline further with age