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Kruisselbrink R, Gharapetian A, Chaparro LE, Ami N, Richler D, Chan VWS, et al

doi: 10.1038/sj.ijo.0801745

Receptor Targets: The Fundamental Difference The simplest way to orient the comparison is by receptor target profile: Semaglutide: GLP-1 receptor agonist only Tirzepatide: Dual GIP receptor + GLP-1 receptor agonist Retatrutide: Triple GLP-1 receptor + GIP receptor + Glucagon receptor agonist Each added receptor target brings a distinct mechanism and research dimension

Regarding other proteases, trypsin and furin can cleave MERS-CoV and SARS-CoV-2 S proteins at the same site 10,15,30,42 and trypsin cleaved the RaTG13 S protein at the S1/S2 cleavage site (at R685/S686 in SARS-CoV-2), whereas trypsin also caused much small fragment derived from S2