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Brain-derived GLP-1 is synthesized in a subset of neurons in the NTS that project to GLP-1Rexpressing regions in the hindbrain and hypothalamus, including the paraventricular nucleus (PVN), dorsal medial nucleus of the hypothalamus, and arcuate nucleus (ARC), as well as the NTS itself

Additionally, some trials are investigating resveratrol as a complementary therapy, evaluating its effects and safety in RA patients while exploring the potential clinical benefits of Nrf2 pathway activation

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