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KEGG pathway enrichment analysis showed that HFD-induced differential metabolites were primarily enriched in pathways including glutathione metabolism, glycerophospholipid metabolism, ferroptosis, fatty acid degradation, and tryptophan metabolism (Fig

Amiodarone is a clinically approved antiarrhythmic agent, active by inhibiting Na + /K + -ATPase and multiple ions channels, including Ca 2+ channels ( 2+ concentrations ( P

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Conclusion and Discussion This study presents a systematic and computationally-driven framework for the design of semaglutide analogues, emphasizing structural and electrostatic optimization to enhance GLP-1R activation

Typically homocysteine, B12 and MMA, folate, and sometimes inflammatory markers