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Clinically, GLP-1RAs like semaglutide induce sweet hyposensitivity and reduce preference for hyperpalatable foods, an effect mediated by changes in endogenous GLP-1 secretion and synaptic plasticity in reward circuits (166)

However, it wasnt until German doctor Max Gerson developed his anticancer therapy that coffee enemas became known worldwide

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American Journal of Psychiatry, 162(5), 977982

Phentermine is a sympathomimetic amine that stimulates the central nervous system to reduce hunger signals, while topiramate, originally developed as an anticonvulsant, increases feelings of fullness and may reduce cravings

GLP-1 medications turn down hunger signals