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The -glutamyl amino acid can be transported back into the cell where -glutamyl cyclo-transferase (GCT) releases the acceptor amino acid to form 5-oxo-proline, the latter of which is converted back to glutamate by oxo-prolinase and used for GSH synthesis

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reported significant improvement in plaque size and penile curvature in patients using daily vitamin E and colchicine compared to ibuprofen alone (16)