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Unpredictable Efficacy: Altering the dosing schedule without scientific backing can lead to unpredictable therapeutic outcomes, potentially rendering the medication less effective or causing erratic responses

Bradshaw et al., 2024

The American Journal of Clinical Nutrition states that, Severe glutathione deficiency is a critical mechanism underlying the oxidative stress and oxidant damage associated with human aging

However, clinically significant pancreatic enzyme elevations were rare

This suggests that different organ-protective mechanisms may have different relationships to adiposity

The company positions the approach as a more accessible alternative for patients who are candidates for isotretinoin therapy but may be hesitant to pursue the oral formulation, including women of childbearing potential