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This duration is typically sufficient for significant tissue repair and recovery

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J Biol Chem 277:2962629633 Murphy MP (2009) How mitochondria produce reactive oxygen species

Importantly, the dose of ferrous iron sulfate used in these studies was 0.15 mmol/kg FeSO 4 (human equivalent dose: 1.85 mg/kg), which is less than the recommended dose for an iron supplement (1 tablet with 325 mg FeSO 4 = 5.4 mg/kg)

Under prolonged oxidative stress, NADPH binds to the enzyme and stabilizes the structure and protects catalase from inactivation