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Code availability All MD simulations were performed and analyzed using the publicly available software tools OpenMM v7.7 [ GaMD-OpenMM [ and MDTraj [ References Zheng, C

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PloS one, 9(4), e94494

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Ethics declarations Ethics approval and consent to participate All animal experiments were conducted after approval from the Institutional Animal Care and Use Committee of the Tongji Medical College, Huazhong University of Science and Technology, and all procedures were in compliance with the relevant guidelines and regulations of the Chinese Council on Animal Care