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The framework takes into account clinical benefits, value for money, societal and ethical considerations, and the economic feasibility of the health care intervention in Ontario

Physiol Rev 98:11691203 Yang M, Vousden KH (2016) Serine and one-carbon metabolism in cancer

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A blood test should always confirm the need before starting

Findings are preliminary, and while they suggest multiple possible biological pathways of interest, further studies are required to clarify mechanisms and implications