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Planning, data collection, study design and analysis, drafting the manuscript

31 Mogensen KM, Robinson MK

59 Scientific evidence indicates that not necessarily the deficiency but the low status of the B 12 biomarker has been associated with increased total Hcy level, which is involved in increased generation of reactive oxygen species in lipid peroxidation and tissue damage to the endothelium vascular and thromboembolism

Given that glutathiones primary function is to neutralize these free radicals, excessive coffee consumption might counteract the antioxidant benefits of glutathione

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doi: 10.1056/NEJMoa1414838 24