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If you notice that a stored peptide requires higher concentrations to achieve previously observed effects, degradation is likely occurring

The interface areas between TMD and GLP-2 contributed by TM1 and TM7 are 864 2 and 432 2 , respectively, markedly larger than those between TMD and GLP-1 (330 2 and 303 2 , respectively)

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Larsen, Fledelius, Knudsen,Tang-Christensen