GIP receptor activation enhances insulin secretion and is hypothesized to affect fat metabolism, while GLP-1 receptor agonism promotes satiety, slows gastric emptying, and reduces appetite
Discontinuing tirzepatide allows these underlying factors to reassert themselves
Like other weight loss medications, tirzepatide mimics two digestive hormones: GLP-1 (glucagon-like peptide-1) and GIP (gastric inhibitory polypeptide)
How To Calculate Tirzepatide Units To determine the correct number of units: Units = (Desired Dose Concentration) 100 Example: Desired dose = 2.5 mg Concentration = 10 mg/mL Units = (2.5 10) 100 Units = 25 This formula works for tirzepatide, semaglutide, and many other medications administered with U-100 insulin syringes
The medications have different receptor profiles and your body needs time to adjust
Alternating between medications doubles the dose-change events, potentially creating more hormonal disruption than staying on a single medication