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Not only does HDL dysfunction result from loss of key proteins and cargo, HDL can gain pro-atherogenic cargo and properties in cardiometabolic diseases

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In the clinical setting, TP508 has failed to display the same beneficial effects as in animal studies

Supplementation with goldenseal (Hydrastis canadensis), but not kava kava (Piper methysticum), inhibits human CYP3A activity in vivo

Int J Clin Pharm

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