A statistical analysis of 11 studies found metformin at doses of 1,700 mg per day increased serum homocysteine and decreased folic acid levels in non-pregnant women with PCOS
Jia F, Fellner A, Kumar KR
doi: 10.1016/0005-2728(94)90180-5
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As well as the expression of SLC7A11 and Nrf2 was decreased by atorvastatin