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Semaglutide, however, can be used long-term

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Specifically, analyzed were the affected brain areas (04), cerebral (NTP-7, Level 3), cerebellar cortex (NTP-7, Level 6), and hippocampus, thalamus, and hypothalamus (NTP-7, Level 3) as follows (score 0 indicates no histopathologic change): score 1: small, patchy, complete, or incomplete infarcts (10% of the area affected)

The compound requires subcutaneous administration for maximum bioavailability, as oral administration results in poor absorption due to first-pass metabolism