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AGL can specifically bind to monoamine oxidase b and HO-1, which helps to inhibit Fe 2+ accumulation and ROS production, thereby maintaining mitochondrial function and preventing ferroptosis

In its lawsuit, the OFA said that the FDAs decision to end the shortage was a reckless and arbitrary move and could deprive patients of a vital treatment for type 2 diabetes and obesity. In an interview with BioSpace last month, David Rosen, partner at Foley & Lardner, said that the lawsuit is a precedent in this area. Prior to the OFA suit, no one has ever challenged the FDAs decision to remove a therapy from the drug shortage list. The OFA case is still ongoing, with the next court update due on Thursday

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Here is the legal framework, quality control gap, and PCAC July 2026 update

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