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10.1007/s00167-018-5321-8 [DOI] [PubMed] [Google Scholar] Kreuz P

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In the GST family, early studies demonstrated that the GSTP1 gene plays an important role in several cellular processes, including catalysis and deoxylation of electrophilic compounds, oxidative stress regulation, cell signaling and carcinogenesis (25,26)

Depletion of GSH could lead to inactivation of SAM synthetase, with further decrease in GSH concentrations

Polyphenols, widely consumed plant-derived compounds, have demonstrated protective effects on the cardiovascular and cerebrovascular systems, with emerging evidence from preclinical stroke models highlighting their neuroprotective potential, even when administered post-stroke (Parrella et al., 2020)