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Another phase 2 RCT studying semglutide 2.4 mg vs placebo in patients with compensated NASH cirrhosis did not show any statistically significant difference in NASH resolution or improvement in liver fibrosis between the groups

Subcutaneous injection bypasses first-pass hepatic metabolism, delivering more active peptide to target tissues

doi: 10.3389/fnut.2023.1209614

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& Micali, G

Peptides 12(4):861863 Westgate CSJ et al (2021) Understanding the link between obesity and headache- with focus on migraine and idiopathic intracranial hypertension