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This mechanism is intentional for weight and metabolic management, but it means your digestive tract is already operating differently than baseline

most positive observational studies have not been adjusted for lifestyle factors

This can lead to unwanted side effects of higher estrogen in men, such as fluid retention, breast tissue enlargement (gynecomastia), and decreased testicular size

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Overall, these findings indicate that reductions in GPx3 abundance trends with disease severity with stage 1 having the highest mean levels of GPx3 (1.99 g/ml 0.73 g/ml) and the highest K1/U1 ratio (0.86), followed by the stage 2 with a mean of 1.2 g/ml 0.54 g/ml and average K2/U2 ratio of 0.67, with the most severe form of konzo, stage 3, displaying the largest reduction in average protein abundance (mean: 1.15 g/ml 0.58 g/ml) and the lowest K3/U3 ratio of 0.59 (Supplementary Data 1)