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(4) M Graf, H Christen, H J Tobler, P F Maier, and G A Schoenenberger (1981) Effects of repeated DSIP and DSIP-P administration on the circadian locomotor activity of rats Pharmacology, Biochemistry and Behaviour, 1981 Nov, Volume 15 (Issue 5), Pages 717-21

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Side effects are rare and typically limited to minor discomfort at the injection site

This pattern is not unique to NAD+, as other nutrients or supplements have experienced similar cycles of hype, backlash, and eventual clarification through further, more rigorous research