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Semaglutide stimulates insulin secretion from pancreatic -cells and inhibits glucagon secretion from pancreatic -cells, thereby reducing fasting and postprandial blood glucose

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The SUSTAIN-6 study demonstrated a 26% reduction in major adverse cardiovascular events (MACE), which includes cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke in high-risk patients with type 2 diabetes

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