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Given (i) that during fetal and early postnatal life, the brain is a fast growing organ, thus very high in energy and nutrient demand [10,11,12,13]

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FIGURE 1 As a free radical, NO could also react with various intracellular/extracellular targets and form a series of molecules, such as NO radicals (NO - ), nitrosonium ions (NO + ), peroxynitrite (ONOO - ), S -nitrosothiols (SNOs), higher oxides of nitrogen (NO x ) and dinitrosyl-iron complexes among others, collectively these NO derivatives are termed reactive nitrogen species (RNS

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