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Metoclopramide (5-10 mg) may be considered for short-term use (less than 12 weeks) under close supervision, as it carries a boxed warning for tardive dyskinesia risk with prolonged use

The integration of these molecular mechanisms, orchestrated by AMPK, underscores metformins comprehensive therapeutic benefits beyond glycemic control, encompassing anti-inflammatory, antioxidant, and cytoprotective effects (Figure 1)

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2003;123(3 Suppl):446S

An open trial compared L-carnitine (500 mg twice daily) alone to 440 mg L-carnitine plus 250 mg L-arginine, 40 mg zinc, 120 mg vitamin E, 80 mg glutathione, 60 mcg selenium, 15 mg CoQ10, and 800 mcg folic acid per day