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SLC31A1 loss depletes mitochondrial copper and promotes cardiac fibrosis

This causes high oxidative stress, mitochondrial dysfunction, and cell death of the hepatocytes.[ref] As these cells die, inflammatory cascades perpetuate the oxidative stress, leading to bleeding, fibrosis, or possibly liver failure

The maintenance dose is generally 1500mcg once a month, or at a schedule determined by the physician based on the patient's ongoing clinical needs and blood test results

In a systematic review and meta-analysis of 16 clinical trials published in the journal "Circulation," coconut oil consumption was shown to increase LDL cholesterol levels by 10.47 mg/dL compared with non-tropical vegetable oils