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When 14C-4-androstenedione was used as substrate (Figure 1), it was metabolised mainly to the diols, testosterone (T), DHT and androstanedione (A)

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For instance, multimodal AI platforms integrate genomic features (such as IFN- response genes), digital pathology images, and ex vivo organoid drug screening data (144, 145), generating patient-specific immunotherapy sensitivity scores with predictive accuracy superior to single biomarkers like PD-L1 IHC

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This approach addresses potential challenges such as apoptosis in the center of organoids and enhances the physiological relevance of the model for studying endometrial function

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