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There is currently a great deal of evidence reinforcing the fact that xenobiotic compounds can penetrate the placental barrier by passive diffusion and/or active transport mechanisms

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Hannaert et al., 2002), while furosemide affects multiple K + Cl transporters and NKCCs (at higher concentrations) (Haas and McManus, 1983;Popowicz and Simmons, 1988;Hegde and Palfrey, 1992